Most antimalarial tablets cause only mild, short-lived side effects such as nausea, headaches or an upset stomach, and the vast majority of travellers complete their course without any serious problems. Even so, knowing what to expect makes it far easier to stay comfortable and, more importantly, to keep taking your tablets as prescribed, because stopping early leaves you unprotected against a disease that can be life-threatening.
In this blog, we will look at the most common antimalarial tablet side effects, how each medication differs, practical ways to manage symptoms, and when to seek professional advice.
Why Do Antimalarial Tablets Cause Side Effects?
Antimalarial drugs for travel work by attacking the malaria parasite at different stages of its life cycle, and this activity can temporarily affect your digestive system, skin or sleep. Side effects are usually a sign your body is adjusting, not that something is wrong.
According to the NHS, no malaria prevention tablets are 100% effective, but taking the right medication correctly, alongside bite avoidance, dramatically reduces your risk.
What Are the Most Common Antimalarial Tablet Side Effects?
Each antimalarial medication has its own side effect profile, so the right choice depends on your destination, health history, and personal preference. Here is what to expect from the three most commonly prescribed options in the UK.
Malarone (Atovaquone with Proguanil)
Malarone antimalarial tablets are generally the best-tolerated option, with side effects that are usually mild. These can include:
- Headaches
- Nausea or stomach upset
- Mild dizziness
- Difficulty sleeping
Doxycycline
Doxycycline is effective and affordable, but it is known for two particular side effects: sun sensitivity and stomach irritation. Travellers may notice the following:
- Increased risk of sunburn, even on cloudy days
- Heartburn or indigestion
- Thrush in some women
Mefloquine (Lariam)
Mefloquine is taken weekly, which many travellers find convenient, though it can affect sleep and mood in a small number of people. Reported effects include vivid dreams, dizziness, and, rarely, anxiety or low mood. It should not be used by people with a history of certain mental health conditions.
How Can You Manage Antimalarial Side Effects?
Most antimalarial medication side effects can be managed with a few simple habits. Try the following:
- Take your tablets with food and a full glass of water to protect your stomach.
- Take doxycycline while sitting upright, and avoid lying down for 30 minutes afterwards.
- Use a high-factor sunscreen and cover up if taking doxycycline.
- Take your dose at the same time each day to build a routine.
- Start your course before travel as directed, so any reaction appears while you are still at home.
When Should You Seek Medical Advice?
Seek medical help promptly if you experience severe symptoms such as persistent vomiting, breathing difficulties, a widespread rash, or significant changes in mood. You should also speak to a pharmacist or GP before stopping any malaria prevention tablets, as TravelHealthPro confirms that incomplete courses leave travellers at real risk of infection.
Get Expert Antimalarial Advice in Tadworth
Planning a trip abroad? Townsend Pharmacy’s travel clinic offers a full range of antimalarial medication in Tadworth, including Malarone, with expert, personalised advice on which option is best for your destination, your health, and your budget. Our pharmacists will explain the possible side effects, help you manage them, and make sure you are fully protected.
Book your antimalarial consultation with us today and travel with confidence.
Frequently Asked Questions
No, most side effects are mild and settle within a few days. Serious reactions are rare, but you should seek medical advice if symptoms are severe or persistent.
Malarone (atovaquone with proguanil) is generally the best-tolerated antimalarial, which is why it is a popular choice despite its higher cost.
No, you should not stop without speaking to a pharmacist first. Stopping early leaves you unprotected, and an alternative medication can usually be arranged.
Most antimalarials require a prescription, although some pharmacies can supply them through a private travel clinic service after a short consultation.
It depends on the medication. Malarone is started 1 to 2 days before travel, doxycycline 2 days before, and mefloquine 3 weeks before, so any side effects show up early.
No medication offers 100% protection. Antimalarials significantly reduce your risk, but you should still use insect repellent, nets, and protective clothing.